Matthew R. Hayes, PhD

Albert J. Stunkard Professor in Psychiatry
Vice Chair of Basic and Translational Neuroscience Research; Director, Molecular and Neural Basis of Psychiatric Disease Section

Department of Psychiatry

Ph.D., Nutritional Sciences, Penn State University

Our laboratory's overarching goal is to identify and characterize the neural signaling pathways controlling for food intake and body weight regulation in an effort to treat obesity and associated co-morbidities. To this end, our research examines the behavioral, intracellular, neuronal, and endocrine mechanisms governing energy balance and how these processes are dysregulated in obesity.

Office Location: 
TRL Building 125 South 31st Street Philadelphia, PA 19104
Research Interests: 

Animal Learning and Behavior

Behavioral Neuroscience


Professor Matthew R. Hayes will be considering new graduate students for admission for Fall 2024.


Selected Publications: 


Borner T, Shaulson ED, Ghidewon MY, Barnett AB, Horn CC, Doyle RP, Grill HJ, Hayes MR*, De Jonghe BC*. GDF15 Induces Anorexia through Nausea and Emesis. Cell Metabolism, 31(2):351-362, 2020.* 

Fortin SM, Lipsky RK, Lhamo R, Chen J, Kim E, Borner T, Schmidt HD, Hayes MR. GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats. Science Translational Medicine, 12 (533): eaay8071, 2020. 

Stein LM, Lhamo R, Cao A, Workinger J, Tinsley I, Doyle RP, Grill HJ, Hermann GE, Rogers RC, Hayes MR. Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation. Translational Psychiatry, 10(1):90, 2020.

Mietlicki-Baase EG, Reiner DJ, Cone JJ, Olivos DR, McGrath LE, Zimmer DJ, Roitman MF, Hayes MR. Amylin Modulates the Mesolimbic Dopamine System to Control Energy Balance. Neuropsychopharmacology: 2014 (In Press – Epub ahead of print).

Mietlicki-Baase EG, Ortinski PI, Reiner DJ, Sinon CG, McCutcheon JE, Pierce RC, Roitman MF, Hayes MR. Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA/kainate signaling. Journal of Neuroscience: 2014 (Epub  ahead of print).

Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR. Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1Receptor Agonists, Liraglutide and Exendin-4. Endocrinology: 152(8):3103-12, 2011.

Hayes MR, Skibicka KP, Leichner TM, DiLeone RJ, Bence KK, Grill HJ. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metabolism, 11(1):77-83, 2010.

Hayes MR, Leichner TM, Zhao S, Lee G, Chowansky A, Zimmer D, De Jonghe BC, Kanoski SE, Grill HJ, Bence KK.  Intracellular signals mediating the food intake suppressive effects of hindbrain glucagon-like-peptide-1 receptor activation. Cell Metabolism, 13(3):320-30, 2011.