Causes and treatments of mood disorders
In my lab we focus on the processes and outcomes of treatments for depression with the goal of understanding the mechanisms of effective treatments and improving the delivery of these treatments to the patients who are most likely to benefit from them. Currently we are developing methods to identify, for a given patient, which of two or more potentially effective treatments (e.g., medications vs. cognitive therapy for depression) is most likely to lead to symptom improvement. We use a variety of information (demographic, personality, genetic, neuropsychological) to generate differential predictions of response, based on models developed with data from randomized trials. We also are working to identify the specific elements or techniques of cognitive therapy that are most likely to be helpful for a given patient (e.g., with or without personality disorder, co-morbid anxiety) from the discovery of process-outcome relationships that vary across patients who present with different profiles.
DeRubeis, R.J., Cohen, Z.D., Forand, N.R., Fournier, J.C., Gelfand, L.A., Lorenzo-Luaces, L. (2014) The Personalized Advantage Index: Translating Research on Prediction into Individualized Treatment Recommendations. A Demonstration. PLoS ONE, 9(1), e83875. doi: e83875.
DeRubeis, R.J., Gelfand, L.A., German, R.E., Fournier, J.C., & Forand, N.R. (2014). Understanding processes of change: How some patients reveal more than others - and some groups of therapists less - about what matters in psychogtherapy. Psycholotherapy Research, 24(3), 419-428.
Lorenzo-Luaces, L., DeRubeis, R. J., & Webb, C. A. (2014). Client characteristics as moderators of the relation between the therapeutic alliance and outcome in cognitive therapy for depression. Journal of Consulting and Clinical Psychology, 82(2), 368.
Webb, C. A., DeRubeis, R. J., Dimidjian, S., Hollon, S. D., Amsterdam, J. D., & Shelton, R. C. (2012). Predictors of patient cognitive therapy skills and symptom change in two randomized clinical trials: The role of therapist adherence and the therapeutic alliance. Journal of Consulting and Clinical Psychology, 80, 373-381.
Webb, C. A., DeRubeis, R. J., Amsterdam, J. D., Shelton, R. C., Hollon, S. D., & Dimidjian, S. (2011). Two aspects of the therapeutic alliance: Differential relations with depressive symptom change. Journal of Consulting and Clinical Psychology, 79, 279-283.
Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Amsterdam, J. D., Shelton, R. C., & Fawcett, J. (2010). Antidepressant drug effects and depression severity: A patient-level meta-analysis. Journal of the American Medical Association, 303, 47-53.
DeRubeis, R. J., Siegle G. J., & Hollon, S. D. (2008). Cognitive therapy versus medication for depression: Treatment outcomes and neural mechanisms. Nature Reviews Neuroscience, 9, 788-796.
Strunk, D. R., DeRubeis R. J., Chiu, A. W., & Alvarez, J. (2007). Patients’ competence in and performance of cognitive therapy skills: Relation to the reduction of relapse risk following treatment for depression. Journal of Consulting and Clinical Psychology, 75, 523-530.
Tang, T. Z., DeRubeis, R. J., Hollon, S. D., Amsterdam, J. A., & Shelton, R. C. (2007). Sudden gains in cognitive therapy of depression and depression relapse/recurrence. Journal of Consulting and Clinical Psychology, 75, 404-408.
DeRubeis, R. J., Hollon, S. D., Amsterdam, J. D., Shelton, R. C., Young, P. R., Salomon, R. M., O’Reardon, J. P., Lovett, M. L., Gladis, M. M., Brown, L. L., & Gallop, R. (2005). Cognitive therapy vs medications in the treatment of moderate to severe depression. Archives of General Psychiatry, 62, 409-416.
Hollon, S. D., DeRubeis, R. J., Shelton, R. C., Amsterdam, J. D., Salomon, R. M., O’Reardon, J. P., Lovett, M. L., Young, P. R., Haman, K. L., Freeman, B. B., & Gallop, R. (2005). Prevention of relapse following cognitive therapy vs medications in moderate to severe depression. Archives of General Psychiatry, 62, 417-422.
DeRubeis, R. J., Brotman, M. A., & Gibbons, C. J. (2005). A conceptual and methodological analysis of the nonspecifics argument. Clinical Psychology: Science and Practice, 12, 174-183.
Lorenzo Lorenzo-Luaces [Psychology Doctoral Candidate]
Jack Keefe [3rd year Psychology Graduate Student]