David Dinges

Professor of Psychiatry

AB, Psychology, St. Benedict's College;

M.S., M.A.(H), Ph.D., Physiological Psychology, Saint Louis University

Office Location: 
1013 Blockley Hall
Phone: 
215-898-9949
Research Interests: 
Behavioral Neuroscience
 

Specific Research Areas:
Sleep, chronobiology, neurobehavioral functions

Research Synopsis:

Our laboratory is a multi-disciplinary group of investigators focused on establishing the nature of, and dynamic changes in, human physiological and neurobehavioral responses produced by sleep loss and circadian chronobiology. Experiments utilizing healthy adult volunteers are conducted in a specially equipped, environmentally isolated Sleep and Chronobiology Laboratory in the Hospital of Pennsylvania (HUP). Basic human translational research within the laboratory characterizes the dynamic relationship between the biological basis of sleep need and circadian physiology, and their control of waking neurobehavioral functions and health, as reflected in mood, physiological alertness, a range of cognitive functions, neuroimaging, quantitative EEG, endocrine, immune, and inflammatory responses. We have a particular interest in discovery of genetic, metabolic, and “omic” biomarkers of differential neurobehavioral vulnerability to sleep loss and stress resilience. The laboratory also conducts field (ambulatory) studies with special technologies that provide information in operational environments—especially those relevant to human space flight (e.g., on the International Space Station; in Antarctica); and we develop neurobehavioral technologies for use in clinical trials and field studies of occupational fatigue. The laboratory also conducts population science on sleep-wake behaviors and noise. The laboratory makes its findings known through scientific publications, and it participates in public policy areas involving human health and safety relative to lifestyle factors that impact sleep need. The research is currently funded by multiple grants from NASA, NIH, and FAA.

Appointments:
Psychology Graduate Group; Neuroscience Graduate Group

 
Advisees:
Olga Tkachenko [Psychology Graduate Student]
 
Professor David Dinges will be considering new graduate students for admission for Fall 2018.
 
Selected Publications: 

Basner M, Dinges DF, Shea J, Small D, Zhu J, Ecker A, Novak C, Bellini L, Volpp K. Sleep and alertness in medical interns and residents: an observational study on the role of extended shifts. SLEEP 40(4), Article Number PII zsx027, Apr. 1, 2017.

Zhang SL, Bai L, Goel N, Bailey A, Jang CJ, Bushman FD, Meerlo P, Dinges DF, Sehgal A. Human and rat gut microbiome composition is maintained following sleep restriction. Proceedings of the National Academy of Sciences of the USA. 114(8), E1564-E1571. Feb. 21, 2017.

Perlis, M.L., Grandner, M.A., Brown, G.K., Basner, M., Chakravorty, S., Morales, K.H., Gehrman, P.R., Chaudhary, N.S., Thase, M.E., Dinges, D.F. Nocturnal wakefulness: Previously unrecognized risk factor for suicide. Journal of Clinical Psychiatry 77(6);e726-e733, 2016.

Weljie AM, Meer P, Goel M, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal AM. Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proceedings of the National Academies of Sciences of the USA. 112(8):2569-2574, 2015.

Basner, M., Rao, H., Goel, N., Dinges, D.F. Sleep deprivation and neurobehavioral dynamics. Current Opinion in Neurobiology, 23:854-863, 2013.

Basner, M.*, Dinges, D.F.*, Mollicone, D.J., Ecker, A.J., Jones, C.W., Hyder, E., Di Antonio, A., Savelev, I., Kan, K., Goel, N., Morukov, B.V., Sutton, J.P., Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing. Proceedings of the National Academies of Sciences of the USA 110(7):2635-2640, 2013.

Minkel, J.D., Banks, S. Htaik, O., Moreta, M.C., Jones, C.W., McGlinchey, E.L., Simpson, N.S., Dinges, D.F. Sleep deprivation and stress: evidence for a lower threshold for subjective stress when sleep deprived. Emotion Feb 6, 2012; e-pub, doi: 10.1037/a0026871.

Basner, M., Dinges, D.F. An adaptive-duration version of the PVT accurately tracks changes in psychomotor vigilance induced by sleep restriction. SLEEP 35(2):193-202, 2012. doi: 10.5665/sleep.162.  PMID:  22294809.  PMCID:  PMC3250358

Gunzelman, G., Gluck, K.A., Moore, R.L., Dinges, D.F. Diminished access to declarative knowledge with sleep deprivation. Cognitive Systems Research 13:1–11, 2012. doi: 10.1016/j.cogsys.2010.09.001

Lim, J., Ebstein, R., Tse, C.Y., Monakhov, M., Lai, P.S., Dinges, D.F., Kwoka, K. Dopaminergic polymorphisms associated with time-on-task declines and subjective fatigue during the Psychomotor Vigilance Test. PLoS ONE 2012;7(3):e33767. Epub 2012 Mar 16, doi: 10.1371/journal.pone.0033767

Goel, N. Dinges, D.F. Predicting risk in space: Genetic markers for differential vulnerability to sleep restriction. Acta Astronautica 77:207-213, 2012. doi:10.1016/j.actaastro.2012.04.002  

Balkin, T.J., Horrey, W.J., Graeber, R.C., Czeisler, C.A., Dinges, D.F. The challenges and opportunities of technological approaches to fatigue management. Accident Analysis and Prevention 43(2):565-72, Mar 2011.  PMID:  21130217

Minkel, J.D., Htaik, O., Banks, S., Dinges, D.F. Emotional expressiveness in sleep-deprived healthy adults. Behavioral Sleep Medicine 9:5-14, 2011. Article Number: PII 931967867   doi: 10.1080/15402002.2011.533987.  PMID:  21218289 

Basner, M., Mollicone, D., Dinges, D.F. Validity and sensitivity of a Brief Psychomotor Vigilance Test (PVT-B) to total and partial sleep deprivation. Acta Astronautica 69:949-959, 2011. doi:10.1016/j.actaastro.2011.07.015.  PMID:  22025811

Goel, N., Banks, S., Lin, L., Mignot, E., Dinges, D.F. Catechol-O-Methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss. PLoS ONE, 6(12):1-10, 27 December 2011.  PMCID:  PMC3246458

Van Dongen, H.P.A., Bender, A.M., Dinges, D.F. Systematic individual differences in sleep homeostatic and circadian rhythm contributions to neurobehavioral impairment during sleep deprivation. Accident Analysis and Prevention, 45S:11-16, 2012, doi:10.1016/j.aap.2011.09.018.  PMID:  22239924  PMCID:  PMC3260461

Basner, M., Dinges, D.F. Maximizing sensitivity of the Psychomotor Vigilance Test (PVT) to sleep loss. SLEEP 34(5):581-591, 2011.

Goel, N., Banks, S., Mignot, E., Dinges, D.F. DQB1*0602 Predicts interindividual differences in physiological sleep, sleepiness and fatigue. Neurology 75:1509-1519, 2010.

Banks, S., Van Dongen, H.P.A., Maislin, G., Dinges, D.F. Neurobehavioral dynamics following chronic sleep restriction: Dose-response effects of one night for recovery. SLEEP 33(8):1013-1026, 2010.

Lim, J., Wu, W-C, Wang, J., Detre, J.A., Dinges, D.F., Rao, H. Imaging brain fatigue from sustained mental workload: An ASL perfusion study of the time-on-task effect, NeuroImage, 49(4): 3426-3435, 2010.  PMID:  19925871

Lim, J., Dinges, D.F. A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychological Bulletin, 136(3): 375-389, 2010.  PMID:  20438143

Goel, N., Banks, S., Mignot, E., Dinges, D.F.: PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS ONE www.plosone.org 4(6):e5874, June 2009.  PMID:  19516903/PMCID:  PMC2689932

McCauley, P, Kalachev, L.V., Smith, A.D., Belenky, G., Dinges, D.F., Van Dongen, H.: A new mathematical model for the homeostatic effects of sleep loss on neurobehavioral performance. Journal of Theoretical Biology 256:227–239, 2009.  PMID:  18938181/PMCID:  PMC2657297

Mollicone, D.J., Van Dongen, H.P.A., Rogers, N.L., Dinges, DF. Response surface mapping of neurobehavioral performance: testing the feasibility of split sleep schedules for space operations. Acta Astronautica 63(7-10): 833-840, 2008.  PMID:  19194521/PMCID:  PMC2633932

Chee, M.L.W., Tan C.H., Hui Z., Parimal S., Weissman S.D., Zagorodnov V., Dinges D.F.: Lapsing during sleep deprivation is associated with distributed changes in brain activation. The Journal of Neuroscience, 28(21):5519-5528, May 21, 2008.  PMID:  18495886

Lim, J., Dinges, D.F.: Sleep deprivation and vigilant attention. Molecular and Biophysical Mechanisms of Arousal, Alertness, and Attention. Annals of the New York Academy of Sciences, 1129:305-322, 2008.  PMID:  18591490