The incidence of obesity has risen dramatically, but currently there are no effective drug treatments. There is an intense effort to identify new and potentially effective drug targets for the treatment of obesity and other pathologies of body weight regulation. Such developments require an understanding of the neural circuits and neurochemical signals that control food intake and energy expenditure. This course focuses on the current literature on energy balance. Students conduct hands-on supervised experiments with animals throughout the week. Class also meets weekly to consider progress in the laboratory and to discuss assigned readings. Research topics come from current issues in the neurology and pharmacology of food and nutrient intake.