The course will begin with an overview of neuroendocrine systems followed by a discussion of the neuroanatomical basis of neuroendocrine systems. There will be a series of lectures on the unique functions of various hormone receptors, including steroid, thyroid and prolactin hormone receptors, all of which are expressed in brain. We also will consider the evidence for local synthesis of steroid hormones in the brain. Hormone secretion will then be considered, comparing the release mechanisms for endocrine- and neural-derived hormones. Finally, we will consider a variety of behavioral issues, including the roles of hormones on sexual behaviors, ingestive behaviors, mood, cognition, and health.