We are a multi-disciplinary group of investigators focused on establishing the nature of and dynamic changes in human physiological and neurobehavioral responses produced by sleep loss and circadian rhythmicity. Experiments utilizing healthy adult volunteers are conducted in a specially equipped, environmentally isolated Sleep and Chronobiology Laboratory and in the NIH Clinical and Translational Research Center at the Hospital of Pennsylvania (HUP). Basic human translational research within the laboratory characterizes the relationship between the biological basis of sleep need and circadian physiology and their control of waking neurobehavioral functions and health, as reflected in mood, physiological alertness, a range of cognitive functions, quantitative EEG/EOG, endocrine, immune, and inflammatory responses. To this end, we are particularly interested in using a variety of techniques (e.g., genetics, brain imaging, psychopharmacology) to identify biomarkers for differential vulnerability to sleep loss and identify differences under basal conditions. The laboratory also conducts studies of population science on sleep-wake behaviors and noise; develops biomathematical and computational models of sleep and circadian effects on behavior; studies of sleep and performance in operational environments—especially those relevant to human space flight (e.g., on the International Space Station); and develops neurobehavioral technology for use in clinical trials and field studies of occupational fatigue. The laboratory makes its findings known through scientific publications, and it participates in public policy areas involving human health and safety relative to lifestyle factors that impact sleep need. The research is currently funded by grants from NIH, NASA, National Space Biomedical Research Institute, Office of Naval Research, and other private and public agencies.
Psychology Graduate Group
Olga Tkachenko [Psychology Graduate Student]
Pellegrino R, Kavakli IH, Goel N, Cardinale C, Dinges DF, Kuna S, Maislin G, Tufik S, Hogenesch JB, Hakonarson H, Pack AI. A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. SLEEP 37(8):1327-36, 2014.
Basner M, Dinges DF, Mollicone DJ, Savelev I, Ecker AJ, Di Antonio A, Jones CW, Hyder E, Kan K, Morukov BV, Sutton JP. Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to Mars. PLoS ONE 9(3), 2014: e93298.
Minkel JD, Moreta M, Muto J, Htaik O, Jones C, Basner M, Dinges DF. Sleep deprivation potentiates HPA axis stress reactivity in healthy adults. Health Psychology (Online First Pub.), May 12, 2014. a0034219.
Shea JA, Dinges DF, Small DS, Basner M, Zhu J, Norton L, Ecker A, Novak C, Bellini LM, Dine CJ, Mollicone DJ, Volpp KG. A randomized trial of a 3-hour protected nap period in a medicine training program: Sleep, alertness and patient outcomes. Academic Medicine, 89(3):452-59, 2014.
McCauley P, Kalachev LV, Mollicone DJ, Banks S, Dinges DF, Van Dongen HPA. Dynamic circadian modulation in a mathematical model for the effects of sleep and sleep loss on waking neurobehavioral performance. SLEEP, 36(12): 1989-99, 2013.
Basner M, Rao H, Goel N, Dinges DF. Sleep deprivation and neurobehavioral dynamics.Current Opinions in Neurobiology, 23:854-863, 2013.
Goel N, Basner M, Rao H, Dinges DF. Circadian rhythms, sleep deprivation and human performance. Chronobiology: Biological Timing in Health and Disease. In: Progress in Molecular Biology and Translational Science, 119: 155-90, 2013.
Spaeth AM, Dinges DF, Goel N. Effects of experimental sleep restriction on weight gain, caloric intake and meal timing in healthy adults. SLEEP 36(7): 981-90, 2013.
Basner M*, Dinges DF*, Mollicone DJ, Ecker AJ, Jones CW, Hyder E, Di Antonio A, Savelev I, Kan K, Goel N, Morukov BV, Sutton JP. Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing. Proceedings of the National Academy of Science of the USA 110(7):2635-40, 2013.
Volpp KG, Shea JA, Small DS, Basner M, Zhu J, Norton L, Ecker A, Novak C, Bellini LM, Dine CJ, Mollicone DJ, Dinges DF. Effect of a protected sleep period on hours slept during extended overnight in-hospital duty hours among medical interns: A randomized trial. Journal of the American Medical Association (JAMA) 308(21):2208-17, 2012.
Spaeth A, Goel N, Dinges DF. Managing neurobehavioral capability when social expediency trumps biological imperatives. Progress in Brain Research 199:377-98, 2012.
Minkel JD, Banks S Htaik O, Moreta MC, Jones CW, McGlinchey EL, Simpson NS, Dinges DF. Sleep deprivation and stress: Evidence for elevated negative affect in response to mild stressors when sleep deprived. Emotion 12(5):1015-20, 2012.
Basner M, Dinges DF. An adaptive-duration version of the PVT accurately tracks changes in psychomotor vigilance induced by sleep restriction. SLEEP 35(2):193-202, 2012.
Lim J, Ebstein R, Tse CY, Monakhov M, Lai PS, Dinges DF, Kwoka K. Dopaminergic polymorphisms associated with time-on-task declines and subjective fatigue during the Psychomotor Vigilance Test. PLoS ONE 2012;7(3):e33767.
Goel N, Dinges DF. Predicting risk in space: Genetic markers for differential vulnerability to sleep restriction. Acta Astronautica 77:207-13, 2012.
Minkel JD, Htaik O, Banks S, Dinges DF. Emotional expressiveness in sleep-deprived healthy adults. Behavioral Sleep Medicine 9:5-14, 2011.
Basner M, Mollicone D, Dinges DF. Validity and sensitivity of a Brief Psychomotor Vigilance Test (PVT-B) to total and partial sleep deprivation. Acta Astronautica 69:949-59, 2011.
Goel N, Banks S, Lin L, Mignot E, Dinges DF. Catechol-O-Methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss. PLoS ONE, 6(12):1-10, 2011.
Basner M, Dinges DF. Maximizing sensitivity of the Psychomotor Vigilance Test (PVT) to sleep loss. SLEEP 34(5):581-91, 2011.
Goel N, Banks S, Mignot E, Dinges DF. DQB1*0602 Predicts interindividual differences in physiological sleep, sleepiness and fatigue. Neurology 75:1509-19, 2010.
Banks S, Van Dongen HPA, Maislin G, Dinges DF. Neurobehavioral dynamics following chronic sleep restriction: Dose-response effects of one night for recovery. SLEEP 33(8):1013-26, 2010.
Lim J, Wu W-C, Wang J, Detre JA, Dinges DF, Rao H. Imaging brain fatigue from sustained mental workload: An ASL perfusion study of the time-on-task effect, NeuroImage, 49(4):3426-35, 2010.
Lim J, Dinges DF. A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychological Bulletin, 136(3): 375-89, 2010.
Goel N, Banks S, Mignot E, Dinges DF. PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS ONE www.plosone.org 4(6):e5874, 2009.
McCauley P, Kalachev LV, Smith AD, Belenky G, Dinges DF, Van Dongen H. A new mathematical model for the homeostatic effects of sleep loss on neurobehavioral performance. Journal of Theoretical Biology 256:227–39, 2009.
Mollicone, DJ, Van Dongen HPA, Rogers NL, Dinges DF. Response surface mapping of neurobehavioral performance: testing the feasibility of split sleep schedules for space operations. Acta Astronautica 63(7-10): 833-40, 2008.
Chee MLW, Tan CH, Hui Z, Parimal S, Weissman SD, Zagorodnov V, Dinges DF. Lapsing during sleep deprivation is associated with distributed changes in brain activation. The Journal of Neuroscience, 28(21):5519-28, May 21, 2008.
Lim J, Dinges DF. Sleep deprivation and vigilant attention. Molecular and Biophysical Mechanisms of Arousal, Alertness, and Attention. Annals of the New York Academy of Sciences, 1129:305-22, 2008.